Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27399093
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27399093
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Medicine+(Baltimore)
2016 ; 95
(27
): e4069
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Cause of death in Chinese Takayasu arteritis patients
#MMPMID27399093
Li J
; Zhu M
; Li M
; Zheng W
; Zhao J
; Tian X
; Zeng X
Medicine (Baltimore)
2016[Jul]; 95
(27
): e4069
PMID27399093
show ga
To analyze the causes of death and the related risk factors for in-patients with
Takayasu arteritis (TAK) admitted to a referral center of China during 1983 to
2014.The medical charts of 12 deceased TAK patients (10 women, 2 men) were
reviewed by two senior rheumatologists. The demographic data, clinical
manifestations, angiographic presentations, and the direct causes of death were
analyzed retrospectively. Medical records of 40 TAK patients (32 women, 8 men)
were selected as controls by age and sex matching method from 81 patients who
were sampled isometrically from 810 successively admitted TAK in-patients of the
same center during the same period. In addition to the comparison of clinical
manifestations between the two groups, binary logistic regression was conducted
to explore the related risk factors of mortality of TAK.Twelve patients died at
the median age of 33.5 (ranging from 13 to 68 years old). The median survival
time was 102.5(ranging from 6 to 567) months. The direct causes of death were
heart failure in 5 (5/12, 41.7%), hemorrhage in 2 (2/12, 16.7%), pulmonary
infection in 2 (2/12, 16.7%), sudden death in 1 (1/12, 8.3%), postoperative
complication in 1 (1/12, 8.3%), and end-stage malignancy in 1 (1/12, 8.3%).
Ischemia (4/12, 33.3%) and hemorrhage (4/12, 33.3%) were the two most common
presentations in deceased patients. Eight patients had received surgical
procedures related to TAK changes. Among them, 2 patients died after surgical
procedure, the other 6 patients died later of non-operation-related causes.
Compared with the control group (n = 40), patients in the deceased group had
longer disease duration (P = 0.017), higher proportion of active disease (P =
0.020), secondary hypertension (P = 0.004), and congestive heart failure (P =
0.017). A model of binary logistic regression had revealed that secondary
hypertension (odds ratio [OR] = 9.333, 95% confidence interval [CI]:
1.721?-?50.614, P = 0.010), congestive heart failure (OR = 5.667, 95% CI:
1.248?-?25.734, P = 0.025), and longer disease duration (OR = 1.007, 95% CI:
1.001?-?0.735, P = 0.027) were risk factors for TAK mortality. Active disease (OR
= 0.167, 95% CI: 0.038?-?50.614, P = 0.018) was negatively associated with death
of TAK.Heart failure is the leading cause of death in TAK patients, followed by
ischemia and pulmonary infection. Early deaths occur postoperatively but become
rare later after the procedure. Well-control of hypertension, and prevention of
congestive heart failure may improve the long-term prognosis.
free
free
free
