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2015 ; 1848
(11 Pt B
): 3047-54
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Cationic antimicrobial peptide resistance mechanisms of streptococcal pathogens
#MMPMID25701232
LaRock CN
; Nizet V
Biochim Biophys Acta
2015[Nov]; 1848
(11 Pt B
): 3047-54
PMID25701232
show ga
Cationic antimicrobial peptides (CAMPs) are critical front line contributors to
host defense against invasive bacterial infection. These immune factors have
direct killing activity toward microbes, but many pathogens are able to resist
their effects. Group A Streptococcus, group B Streptococcus and Streptococcus
pneumoniae are among the most common pathogens of humans and display a variety of
phenotypic adaptations to resist CAMPs. Common themes of CAMP resistance
mechanisms among the pathogenic streptococci are repulsion, sequestration,
export, and destruction. Each pathogen has a different array of CAMP-resistant
mechanisms, with invasive disease potential reflecting the utilization of several
mechanisms that may act in synergy. Here we discuss recent progress in
identifying the sources of CAMP resistance in the medically important
Streptococcus genus. Further study of these mechanisms can contribute to our
understanding of streptococcal pathogenesis, and may provide new therapeutic
targets for therapy and disease prevention. This article is part of a Special
Issue entitled: Bacterial Resistance to Antimicrobial Peptides.
|*Drug Resistance, Bacterial
[MESH]
|Animals
[MESH]
|Anti-Bacterial Agents/therapeutic use
[MESH]
|Antimicrobial Cationic Peptides/immunology/*metabolism/therapeutic use
[MESH]
|Bacterial Proteins/immunology/*metabolism
[MESH]
|Biological Transport
[MESH]
|Host-Pathogen Interactions
[MESH]
|Humans
[MESH]
|Immune Evasion
[MESH]
|Immunity, Innate
[MESH]
|Membrane Transport Proteins/metabolism
[MESH]
|Microbial Viability
[MESH]
|Proteolysis
[MESH]
|Signal Transduction
[MESH]
|Streptococcal Infections/immunology/*metabolism/microbiology/prevention & control
[MESH]