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2015 ; 54
(21
): 6110-50
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Catenanes: fifty years of molecular links
#MMPMID25951013
Gil-Ramírez G
; Leigh DA
; Stephens AJ
Angew Chem Int Ed Engl
2015[May]; 54
(21
): 6110-50
PMID25951013
show ga
Half a century after Schill and Lüttringhaus carried out the first directed
synthesis of a [2]catenane, a plethora of strategies now exist for the
construction of molecular Hopf links (singly interlocked rings), the simplest
type of catenane. The precision and effectiveness with which suitable templates
and/or noncovalent interactions can arrange building blocks has also enabled the
synthesis of intricate and often beautiful higher order interlocked systems,
including Solomon links, Borromean rings, and a Star of David catenane. This
Review outlines the diverse strategies that exist for synthesizing catenanes in
the 21st century and examines their emerging applications and the challenges that
still exist for the synthesis of more complex topologies.