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10.1101/cshperspect.a008656 http://scihub22266oqcxt.onion/10.1101/cshperspect.a008656 C3683896!3683896 !23545416     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\23545416 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cold+Spring+Harb+Perspect+Biol 2013 ; 5 (4 ): a008656 Nephropedia Template TP {{tp|p=23545416 |t=2013. Caspase functions in cell death and disease |pdf=|usr=}}{{23545416 }} gab.com Text Caspase functions in cell death and disease JO: Cold Spring Harb Perspect Biol http://www.kidney.de/pget.php?&tw=1&pmid=23545416 #FOAvip Caspases are a family of endoproteases that provide critical links in cell regulatory networks controlling inflammation and cell death. The activation of these enzymes is tightly controlled by their production as inactive zymogens that gain catalytic activity following signaling events promoting their aggregation into dimers or macromolecular complexes. Activation of apoptotic caspases results in inactivation or activation of substrates, and the generation of a cascade of signaling events permitting the controlled demolition of cellular components. Activation of inflammatory caspases results in the production of active proinflammatory cytokines and the promotion of innate immune responses to various internal and external insults. Dysregulation of caspases underlies human diseases including cancer and inflammatory disorders, and major efforts to design better therapies for these diseases seek to understand how these enzymes work and how they can be controlled. Twit Text FOAVip Caspase functions in cell death and disease ????Cold Spring Harb Perspect Biol http://www.kidney.de/pget.php?&tw=1&pmid=23545416 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23545416 #FOAvip English Wikipedia <ref>{{Cite pmid|23545416 }}</ref> Caspase functions in cell death and disease #MMPMID23545416 McIlwain DR ; Berger T ; Mak TW Cold Spring Harb Perspect Biol 2013[Apr]; 5 (4 ): a008656 PMID23545416 show ga Caspases are a family of endoproteases that provide critical links in cell regulatory networks controlling inflammation and cell death. The activation of these enzymes is tightly controlled by their production as inactive zymogens that gain catalytic activity following signaling events promoting their aggregation into dimers or macromolecular complexes. Activation of apoptotic caspases results in inactivation or activation of substrates, and the generation of a cascade of signaling events permitting the controlled demolition of cellular components. Activation of inflammatory caspases results in the production of active proinflammatory cytokines and the promotion of innate immune responses to various internal and external insults. Dysregulation of caspases underlies human diseases including cancer and inflammatory disorders, and major efforts to design better therapies for these diseases seek to understand how these enzymes work and how they can be controlled. |*Apoptosis [MESH] |Animals [MESH] |Caspases/*metabolism/physiology [MESH] |Cell Death [MESH] |Dimerization [MESH] |Gene Expression Regulation [MESH] |Humans [MESH] |Immunity, Innate [MESH] |Inflammation [MESH] |Mice [MESH] |Necrosis [MESH] |Neoplasms/metabolism [MESH] |Signal Transduction [MESH]Caspase functions in cell death and disease (epmc).pdf DeepDyve Pubget Overpricing