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10.1371/journal.pone.0152683 http://scihub22266oqcxt.onion/10.1371/journal.pone.0152683 C4816323!4816323 !27031353     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27031353 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27031353 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+One 2016 ; 11 (3 ): e0152683 Nephropedia Template TP {{tp|p=27031353 |t=2016. Cas9 Functionally Opens Chromatin |pdf=|usr=}}{{27031353 }} gab.com Text Cas9 Functionally Opens Chromatin JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=27031353 #FOAvip Using a nuclease-dead Cas9 mutant, we show that Cas9 reproducibly induces chromatin accessibility at previously inaccessible genomic loci. Cas9 chromatin opening is sufficient to enable adjacent binding and transcriptional activation by the settler transcription factor retinoic acid receptor at previously unbound motifs. Thus, we demonstrate a new use for Cas9 in increasing surrounding chromatin accessibility to alter local transcription factor binding. Twit Text FOAVip Cas9 Functionally Opens Chromatin ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=27031353 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27031353 #FOAvip English Wikipedia <ref>{{Cite pmid|27031353 }}</ref> Cas9 Functionally Opens Chromatin #MMPMID27031353 Barkal AA ; Srinivasan S ; Hashimoto T ; Gifford DK ; Sherwood RI PLoS One 2016[]; 11 (3 ): e0152683 PMID27031353 show ga Using a nuclease-dead Cas9 mutant, we show that Cas9 reproducibly induces chromatin accessibility at previously inaccessible genomic loci. Cas9 chromatin opening is sufficient to enable adjacent binding and transcriptional activation by the settler transcription factor retinoic acid receptor at previously unbound motifs. Thus, we demonstrate a new use for Cas9 in increasing surrounding chromatin accessibility to alter local transcription factor binding. |*CRISPR-Cas Systems [MESH] |*Transcriptional Activation [MESH] |Animals [MESH] |CRISPR-Associated Proteins/genetics/*metabolism [MESH] |Cell Line [MESH] |Chromatin/genetics/*metabolism [MESH] |Genetic Loci [MESH] |Genome [MESH] |Mice [MESH] |Mouse Embryonic Stem Cells/metabolism [MESH] |Mutation [MESH]Cas9 Functionally Opens Chromatin (epmc).pdf DeepDyve Pubget Overpricing