Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText.
Kick-your-searchterm to multiple Engines kick-your-query now !>
A dictionary by aggregated review articles of nephrology, medicine and the life sciences
Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

suck abstract from ncbi


10.1073/pnas.1707936115

http://scihub22266oqcxt.onion/10.1073/pnas.1707936115
suck pdf from google scholar
C5776960!5776960 !29295928
unlimited free pdf from europmc29295928
    free
PDF from PMC    free
html from PMC    free

Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29295928 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215

suck abstract from ncbi


Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29295928 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117
pmid29295928
      Proc+Natl+Acad+Sci+U+S+A 2018 ; 115 (3 ): 537-542
Nephropedia Template TP

gab.com Text

Twit Text FOAVip

Twit Text #

English Wikipedia


  • Cargo navigation across 3D microtubule intersections #MMPMID29295928
  • Bergman JP ; Bovyn MJ ; Doval FF ; Sharma A ; Gudheti MV ; Gross SP ; Allard JF ; Vershinin MD
  • Proc Natl Acad Sci U S A 2018[Jan]; 115 (3 ): 537-542 PMID29295928 show ga
  • The eukaryotic cell's microtubule cytoskeleton is a complex 3D filament network. Microtubules cross at a wide variety of separation distances and angles. Prior studies in vivo and in vitro suggest that cargo transport is affected by intersection geometry. However, geometric complexity is not yet widely appreciated as a regulatory factor in its own right, and mechanisms that underlie this mode of regulation are not well understood. We have used our recently reported 3D microtubule manipulation system to build filament crossings de novo in a purified in vitro environment and used them to assay kinesin-1-driven model cargo navigation. We found that 3D microtubule network geometry indeed significantly influences cargo routing, and in particular that it is possible to bias a cargo to pass or switch just by changing either filament spacing or angle. Furthermore, we captured our experimental results in a model which accounts for full 3D geometry, stochastic motion of the cargo and associated motors, as well as motor force production and force-dependent behavior. We used a combination of experimental and theoretical analysis to establish the detailed mechanisms underlying cargo navigation at microtubule crossings.
  • |Biological Transport [MESH]
  • |Cytoskeleton/metabolism [MESH]
  • |Humans [MESH]
  • |Imaging, Three-Dimensional [MESH]
  • |Kinesins/chemistry/metabolism [MESH]
  • |Kinetics [MESH]
  • |Microtubules/*chemistry/*metabolism [MESH]
  • |Models, Biological [MESH]
  • |Models, Theoretical [MESH]


  • DeepDyve
  • Pubget Overpricing
  • suck abstract from ncbi

    Linkout box