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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Endocrinol+Invest
2008 ; 31
(10
): 925-31
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Cardiovascular aspects of primary hyperparathyroidism
#MMPMID19092300
Walker MD
; Silverberg SJ
J Endocrinol Invest
2008[Oct]; 31
(10
): 925-31
PMID19092300
show ga
Data concerning the cardiovascular manifestations of primary hyperparathyroidism
(PHPT) are inconsistent, which is due, in part, to the decrease in disease
severity over the last several decades. In areas where patients tend to be more
symptomatic, data support the presence of cardiovascular findings including
myocardial and vascular calcification as well as increased cardiovascular
mortality. Data from the cohorts in whom the disease is characterized by mild
hypercalcemia, suggest that clinically overt cardiovascular manifestations are
unusual in PHPT. Recent data, however, support the presence of subtle
cardiovascular manifestations in mild disease, such as changes in endothelial
function as well as increased vascular stiffness and perhaps diastolic
dysfunction. Left ventricular hypertrophy is a more consistent finding across a
spectrum of disease severity, though this finding may be related to hypertension,
which has long been associated with PHPT.