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2008 ; 8
(ä): 384-93
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Cardiovascular activities of the bradykinin system
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Sharma JN
ScientificWorldJournal
2008[Apr]; 8
(ä): 384-93
PMID18454246
show ga
All the components of the kallikrein-kinin system are located in the cardiac
muscle and its deficiency may lead to cardiac dysfunction. In recent years,
numerous observations obtained from clinical and experimental models of diabetes,
hypertension, cardiac failure, ischemia, myocardial infarction, and left
ventricular hypertrophy have suggested that the reduced activity of the local
kallikrein-kinin system may be instrumental for the induction of
cardiovascular-related diseases. The cardioprotective property of the
angiotensin-converting enzyme inhibitors is primarily mediated via a
kinin-releasing pathway, which may cause regression of the left ventricular
hypertrophy in hypertensive situations. The ability of kallikrein gene delivery
to produce a wide spectrum of beneficial effects makes it a promising candidate
in treating hypertension and cardiovascular and renal diseases. In addition,
stable kinin agonists may also be available in the future as therapeutic agents
for cardiovascular and renal disorders. However, there are also possibilities of
adverse effects that may be caused by these compounds.
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