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2015 ; 22
(18
): 1667-80
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Cardiolipin signaling mechanisms: collapse of asymmetry and oxidation
#MMPMID25566681
Kagan VE
; Tyurina YY
; Tyurin VA
; Mohammadyani D
; Angeli JP
; Baranov SV
; Klein-Seetharaman J
; Friedlander RM
; Mallampalli RK
; Conrad M
; Bayir H
Antioxid Redox Signal
2015[Jun]; 22
(18
): 1667-80
PMID25566681
show ga
SIGNIFICANCE: An ancient anionic phospholipid, cardiolipin (CL), ubiquitously
present in prokaryotic and eukaryotic membranes, is essential for several
structural and functional purposes. RECENT ADVANCES: The emerging role of CLs in
signaling has become the focus of many studies. CRITICAL ISSUES: In this work, we
describe two major pathways through which mitochondrial CLs may fulfill the
signaling functions via utilization of their (i) asymmetric distribution across
membranes and translocations, leading to the surface externalization and (ii)
ability to undergo oxidation reactions to yield the signature products
recognizable by the executionary machinery of cells. FUTURE DIRECTIONS: We
present a concept that CLs and their oxidation/hydrolysis products constitute a
rich communication language utilized by mitochondria of eukaryotic cells for
diversified regulation of cell physiology and metabolism as well as for
inter-cellular interactions.