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2015 ; 11
(1
): 1-46
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Cardiac purinergic signalling in health and disease
#MMPMID25527177
Burnstock G
; Pelleg A
Purinergic Signal
2015[Mar]; 11
(1
): 1-46
PMID25527177
show ga
This review is a historical account about purinergic signalling in the heart, for
readers to see how ideas and understanding have changed as new experimental
results were published. Initially, the focus is on the nervous control of the
heart by ATP as a cotransmitter in sympathetic, parasympathetic, and sensory
nerves, as well as in intracardiac neurons. Control of the heart by centers in
the brain and vagal cardiovascular reflexes involving purines are also discussed.
The actions of adenine nucleotides and nucleosides on cardiomyocytes,
atrioventricular and sinoatrial nodes, cardiac fibroblasts, and coronary blood
vessels are described. Cardiac release and degradation of ATP are also described.
Finally, the involvement of purinergic signalling and its therapeutic potential
in cardiac pathophysiology is reviewed, including acute and chronic heart
failure, ischemia, infarction, arrhythmias, cardiomyopathy, syncope, hypertrophy,
coronary artery disease, angina, diabetic cardiomyopathy, as well as heart
transplantation and coronary bypass grafts.