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2017 ; 9
(Suppl 1
): S36-S51
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Cardiac fibroblasts: more than mechanical support
#MMPMID28446967
Doppler SA
; Carvalho C
; Lahm H
; Deutsch MA
; Dreßen M
; Puluca N
; Lange R
; Krane M
J Thorac Dis
2017[Mar]; 9
(Suppl 1
): S36-S51
PMID28446967
show ga
Fibroblasts are cells with a structural function, synthesizing components of the
extracellular matrix. They are accordingly associated with various forms of
connective tissue. During cardiac development fibroblasts originate from
different sources. Most derive from the epicardium, some derive from the
endocardium, and a small population derives from the neural crest. Cardiac
fibroblasts have important functions during development, homeostasis, and
disease. However, since fibroblasts are a very heterogeneous cell population no
truly specific markers exist. Therefore, studying them in detail is difficult.
Nevertheless, several lineage tracing models have been widely used. In this
review, we describe the developmental origins of cardiac fibroblasts, comment on
fibroblast markers and related lineage tracing approaches, and discuss the
cardiac cell composition, which has recently been revised, especially in terms of
non-myocyte cells.