Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26044255
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Circ+Res
2015 ; 116
(12
): 2041-9
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Cardiac arrest: resuscitation and reperfusion
#MMPMID26044255
Patil KD
; Halperin HR
; Becker LB
Circ Res
2015[Jun]; 116
(12
): 2041-9
PMID26044255
show ga
The modern treatment of cardiac arrest is an increasingly complex medical
procedure with a rapidly changing array of therapeutic approaches designed to
restore life to victims of sudden death. The 2 primary goals of providing
artificial circulation and defibrillation to halt ventricular fibrillation remain
of paramount importance for saving lives. They have undergone significant
improvements in technology and dissemination into the community subsequent to
their establishment 60 years ago. The evolution of artificial circulation
includes efforts to optimize manual cardiopulmonary resuscitation, external
mechanical cardiopulmonary resuscitation devices designed to augment circulation,
and may soon advance further into the rapid deployment of specially designed
internal emergency cardiopulmonary bypass devices. The development of
defibrillation technologies has progressed from bulky internal defibrillators
paddles applied directly to the heart, to manually controlled external
defibrillators, to automatic external defibrillators that can now be obtained
over-the-counter for widespread use in the community or home. But the modern
treatment of cardiac arrest now involves more than merely providing circulation
and defibrillation. As suggested by a 3-phase model of treatment, newer
approaches targeting patients who have had a more prolonged cardiac arrest
include treatment of the metabolic phase of cardiac arrest with therapeutic
hypothermia, agents to treat or prevent reperfusion injury, new strategies
specifically focused on pulseless electric activity, which is the presenting
rhythm in at least one third of cardiac arrests, and aggressive post
resuscitation care. There are discoveries at the cellular and molecular level
about ischemia and reperfusion pathobiology that may be translated into future
new therapies. On the near horizon is the combination of advanced cardiopulmonary
bypass plus a cocktail of multiple agents targeted at restoration of normal
metabolism and prevention of reperfusion injury, as this holds the promise of
restoring life to many patients for whom our current therapies fail.
|Calcium Signaling
[MESH]
|Cardiopulmonary Resuscitation/*methods
[MESH]
|Cardiovascular Agents/adverse effects/therapeutic use
[MESH]
free
free
free
