Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27586288
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Curr+Top+Membr
2016 ; 78
(ä): 287-311
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Cardiac Na Channels: Structure to Function
#MMPMID27586288
DeMarco KR
; Clancy CE
Curr Top Membr
2016[]; 78
(ä): 287-311
PMID27586288
show ga
Heart rhythms arise from electrical activity generated by precisely timed opening
and closing of ion channels in individual cardiac myocytes. Opening of the
primary cardiac voltage-gated sodium (NaV1.5) channel initiates cellular
depolarization and the propagation of an electrical action potential that
promotes coordinated contraction of the heart. The regularity of these
contractile waves is critically important since it drives the primary function of
the heart: to act as a pump that delivers blood to the brain and vital organs.
When electrical activity goes awry during a cardiac arrhythmia, the pump does not
function, the brain does not receive oxygenated blood, and death ensues.
Perturbations to NaV1.5 may alter the structure, and hence the function, of the
ion channel and are associated downstream with a wide variety of cardiac
conduction pathologies, such as arrhythmias.
free
free
free
