Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25000109
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Int+J+Occup+Environ+Health
2014 ; 20
(3
): 215-9
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Carcinogenic effects of aflatoxin B1 among wheat handlers
#MMPMID25000109
Saad-Hussein A
; Taha MM
; Beshir S
; Shahy EM
; Shaheen W
; Elhamshary M
Int J Occup Environ Health
2014[Jul]; 20
(3
): 215-9
PMID25000109
show ga
BACKGROUND: Epidemiological studies have demonstrated that serum aflatoxin B1
(AFB1) is a hepatocarcinogenic mycotoxin and contributor to the high rate of
hepatocellular carcinoma (HCC). The prevalence of liver cancer in Egypt is
particularly worrisome. In a registry-based analysis of occupational risk for
HCC, significant excesses were observed especially for grain mill workers.
OBJECTIVE: The aim of this study was to assess the hepatic carcinogenicity of
AFB1 in wheat handlers. METHODS: Serum AFB1/albumin (AFB1/Alb), alpha-fetoprotein
(AFP), alpha-l-fucosidase (AFU), and arginase were estimated in exposed wheat
handlers including millers and bakers. The control group was composed of
non-occupationally exposed workers. RESULTS: AFB1/Alb and AFU were significantly
higher among workers employed as bakers compared to mill workers and controls.
Mill workers had higher levels of AFB1/Alb than the controls. AFB1/Alb, AFP, and
AFU were all significantly higher and arginase was significantly lower among HCC
cases compared to the other groups. There was a significant correlation between
AFU and AFB1/Alb in bakers and between AFP and AFB1/Alb in HCC cases. Arginase
was inversely correlated with AFB1/Alb in HCC cases. AFB1/Alb was significantly
correlated with the duration of exposure in bakers. CONCLUSION: Wheat handlers
exposed to Aspergillus flavus have a high risk of elevated serum AFB1/Alb levels
and AFU.
free
free
free
