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10.18632/oncotarget.25165 http://scihub22266oqcxt.onion/10.18632/oncotarget.25165 C5955418!5955418 !29796166     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29796166 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2018 ; 9 (33 ): 22976-22985 Nephropedia Template TP {{tp|p=29796166 |t=2018. Carbon ion radiotherapy for inoperable pediatric osteosarcoma |pdf=|usr=}}{{29796166 }} gab.com Text Carbon ion radiotherapy for inoperable pediatric osteosarcoma JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29796166 #FOAvip BACKGROUND: Unresectable pediatric osteosarcoma has poor outcomes with conventional treatments. RESULTS: Twenty-six patients aged 11-20 years (median 16) had inoperable osteosarcoma of the trunk (24 pelvic, 1 mediastinal and 1 paravertebral) without any other lesion at initial examination. There were 22 primary, 1 locally recurrent and 3 metastatic cases. Median CIRT dose was 70.4 Gy RBE (relative biological effectiveness) delivered in 16 fractions. Median follow-up was 32.7 months. Overall survival was 50.0% and 41.7% at 3 and 5 years, respectively. Ten patients survived for more than 5 years (range 5-20.7 years). Local control was 69.9% and 62.9% at 3 and 5 years, respectively and progression-free survival was 34.6% at 3 and 5 years. Only largest tumor diameter correlated with 5-year overall survival and local control. There were 4 grade 3-4 CIRT-related late toxicities, 1 case of bone fracture and no treatment-related mortalities. All patients (except 1) were able to ambulate after CIRT. CONCLUSIONS: CIRT was safe and efficacious in the treatment of inoperable pediatric osteosarcoma with improved local control and overall survival compared to conventional treatments. METHODS: We retrospectively reviewed the records of pediatric and adolescent patients who received carbon ion radiotherapy (CIRT) for inoperable osteosarcoma between 1996 and 2014. Twit Text FOAVip Carbon ion radiotherapy for inoperable pediatric osteosarcoma ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29796166 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29796166 #FOAvip English Wikipedia <ref>{{Cite pmid|29796166 }}</ref> Carbon ion radiotherapy for inoperable pediatric osteosarcoma #MMPMID29796166 Mohamad O ; Imai R ; Kamada T ; Nitta Y ; Araki N Oncotarget 2018[May]; 9 (33 ): 22976-22985 PMID29796166 show ga BACKGROUND: Unresectable pediatric osteosarcoma has poor outcomes with conventional treatments. RESULTS: Twenty-six patients aged 11-20 years (median 16) had inoperable osteosarcoma of the trunk (24 pelvic, 1 mediastinal and 1 paravertebral) without any other lesion at initial examination. There were 22 primary, 1 locally recurrent and 3 metastatic cases. Median CIRT dose was 70.4 Gy RBE (relative biological effectiveness) delivered in 16 fractions. Median follow-up was 32.7 months. Overall survival was 50.0% and 41.7% at 3 and 5 years, respectively. Ten patients survived for more than 5 years (range 5-20.7 years). Local control was 69.9% and 62.9% at 3 and 5 years, respectively and progression-free survival was 34.6% at 3 and 5 years. Only largest tumor diameter correlated with 5-year overall survival and local control. There were 4 grade 3-4 CIRT-related late toxicities, 1 case of bone fracture and no treatment-related mortalities. All patients (except 1) were able to ambulate after CIRT. CONCLUSIONS: CIRT was safe and efficacious in the treatment of inoperable pediatric osteosarcoma with improved local control and overall survival compared to conventional treatments. METHODS: We retrospectively reviewed the records of pediatric and adolescent patients who received carbon ion radiotherapy (CIRT) for inoperable osteosarcoma between 1996 and 2014. äCarbon ion radiotherapy for inoperable pediatric osteosarcoma (epmc).pdf DeepDyve Pubget Overpricing