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2017 ; 25
(1
): 15-24
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Capturing genomic relationships that matter
#MMPMID28078515
Osborne CS
; Mifsud B
Chromosome Res
2017[Mar]; 25
(1
): 15-24
PMID28078515
show ga
There is a strong interrelationship within the cell nucleus between form and
function of the genome. This connection is exhibited across multiple hierarchies,
ranging from grand-scale positioning of chromosomes and their intersection with
specific nuclear functional activities, the segregation of chromosome structure
into distinct domains and long-range regulatory contacts that drive spatial and
temporal expression patterns of genes. Fifteen years ago, the development of the
chromosome conformation capture method placed the nature of specific, long-range
regulatory interactions under scrutiny. However, its development and integration
with next-generation sequencing technologies has greatly expanded the breadth and
scope of what is detected. The sheer scale of data offered by these important
advances has come with new and challenging bottlenecks that are both experimental
and bioinformatical. Here, we discuss the recent and prospective development and
implementation of new methodologies and analytical tools that are allowing an
in-depth, yet focussed characterisation of genomic contacts that are associated
with functional activities in the nucleus.
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