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2014 ; 22
(12
): 707-14
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Candida albicans hyphal initiation and elongation
#MMPMID25262420
Lu Y
; Su C
; Liu H
Trends Microbiol
2014[Dec]; 22
(12
): 707-14
PMID25262420
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The fungus Candida albicans is a benign member of the mucosal microbiota, but can
cause mucosal infections and life-threatening disseminated invasive infections in
susceptible individuals. The ability to switch between yeast, pseudohyphal, and
hyphal growth forms (polymorphism) is one of the most investigated virulence
attributes of C. albicans. Recent studies suggest that hyphal development in C.
albicans requires two temporally linked regulations for initiation and
maintenance of the hyphal transcriptional program. Hyphal initiation requires a
rapid but temporary disappearance of the Nrg1 transcriptional repressor of hyphal
morphogenesis. Hyphal maintenance requires active sensing of the surrounding
environment, leading to exclusion of Nrg1 binding to promoters of hypha-specific
genes or reduced NRG1 expression. We discuss recent advances in understanding the
complex transcriptional regulation of hyphal gene expression. These provide
molecular mechanisms underpinning the phenotypic plasticity of C. albicans
polymorphism.
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