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2018 ; 4
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Candida albicans Hyphae: From Growth Initiation to Invasion
#MMPMID29371503
Desai JV
J Fungi (Basel)
2018[Jan]; 4
(1
): ä PMID29371503
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Candida albicans is a commensal resident of the human gastrointestinal and
genital tracts. Under conditions such as dysbiosis, host immune perturbances, or
the presence of catheters/implanted medical devices, the fungus may cause
debilitating mucosal or fatal systemic infections. The ability of C. albicans to
grow as long filamentous hyphae is critical for its pathogenic potential as it
allows the fungus to invade the underlying substratum. In this brief review, I
will outline the current understanding regarding the mechanistic regulation of
hyphal growth and invasion in C. albicans.