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2016 ; 4
(ä): 126
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Cancer-Related Functions and Subcellular Localizations of Septins
#MMPMID27878118
Poüs C
; Klipfel L
; Baillet A
Front Cell Dev Biol
2016[]; 4
(ä): 126
PMID27878118
show ga
Since the initial discovery of septin family GTPases, the understanding of their
molecular organization and cellular roles keeps being refined. Septins have been
involved in many physiological processes and the misregulation of specific septin
gene expression has been implicated in diverse human pathologies, including
neurological disorders and cancer. In this minireview, we focus on the importance
of the subunit composition and subcellular localization of septins relevant to
tumor initiation, progression, and metastasis. We especially underline the
importance of septin polymer composition and of their association with the plasma
membrane, actin, or microtubules in cell functions involved in cancer and in
resistance to cancer therapies. Through their scaffolding role, their function in
membrane compartmentalization or through their protective function against
protein degradation, septins also emerge as critical organizers of
membrane-associated proteins and of signaling pathways implicated in
cancer-associated angiogenesis, apoptosis, polarity, migration, proliferation,
and in metastasis. Also, the question as to which of the free monomers,
hetero-oligomers, or filaments is the functional form of mammalian septins is
raised and the control over their spatial and temporal localization is discussed.
The increasing amount of crosstalks identified between septins and cellular
signaling mediators reinforces the exciting possibility that septins could be new
targets in anti-cancer therapies or in therapeutic strategies to limit drug
resistance.