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2015 ; 29
(12
): 1203-17
Nephropedia Template TP
Genes Dev
2015[Jun]; 29
(12
): 1203-17
PMID26109046
show ga
Tissues with defined cellular hierarchies in development and homeostasis give
rise to tumors with cellular hierarchies, suggesting that tumors recapitulate
specific tissues and mimic their origins. Glioblastoma (GBM) is the most
prevalent and malignant primary brain tumor and contains self-renewing,
tumorigenic cancer stem cells (CSCs) that contribute to tumor initiation and
therapeutic resistance. As normal stem and progenitor cells participate in tissue
development and repair, these developmental programs re-emerge in CSCs to support
the development and progressive growth of tumors. Elucidation of the molecular
mechanisms that govern CSCs has informed the development of novel targeted
therapeutics for GBM and other brain cancers. CSCs are not self-autonomous units;
rather, they function within an ecological system, both actively remodeling the
microenvironment and receiving critical maintenance cues from their niches. To
fulfill the future goal of developing novel therapies to collapse CSC dynamics,
drawing parallels to other normal and pathological states that are highly
interactive with their microenvironments and that use developmental signaling
pathways will be beneficial.
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