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2016 ; 7
(10
): 11002-17
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Cancer stem cells and signaling pathways in radioresistance
#MMPMID26716904
Chang L
; Graham P
; Hao J
; Ni J
; Deng J
; Bucci J
; Malouf D
; Gillatt D
; Li Y
Oncotarget
2016[Mar]; 7
(10
): 11002-17
PMID26716904
show ga
Radiation therapy (RT) is one of the most important strategies in cancer
treatment. Radioresistance (the failure to RT) results in locoregional recurrence
and metastasis. Therefore, it is critically important to investigate the
mechanisms leading to cancer radioresistance to overcome this problem and
increase patients' survival. Currently, the majority of the
radioresistance-associated researches have focused on preclinical studies.
Although the exact mechanisms of cancer radioresistance have not been fully
uncovered, accumulating evidence supports that cancer stem cells (CSCs) and
different signaling pathways play important roles in regulating radiation
response and radioresistance. Therefore, targeting CSCs or signaling pathway
proteins may hold promise for developing novel combination modalities and
overcoming radioresistance. The present review focuses on the key evidence of CSC
markers and several important signaling pathways in cancer radioresistance and
explores innovative approaches for future radiation treatment.
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