Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27611937
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27611937
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Medicine+(Baltimore)
2016 ; 95
(1 Suppl 1
): S8-S19
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Cancer stem cell signaling pathways
#MMPMID27611937
Matsui WH
Medicine (Baltimore)
2016[Sep]; 95
(1 Suppl 1
): S8-S19
PMID27611937
show ga
Tissue development and homeostasis are governed by the actions of stem cells.
Multipotent cells are capable of self-renewal during the course of one's
lifetime. The accurate and appropriate regulation of stem cell functions is
absolutely critical for normal biological activity. Several key developmental or
signaling pathways have been shown to play essential roles in this regulatory
capacity. Specifically, the Janus-activated kinase/signal transducer and
activator of transcription, Hedgehog, Wnt, Notch, phosphatidylinositol
3-kinase/phosphatase and tensin homolog, and nuclear factor-?B signaling pathways
have all been shown experimentally to mediate various stem cell properties, such
as self-renewal, cell fate decisions, survival, proliferation, and
differentiation. Unsurprisingly, many of these crucial signaling pathways are
dysregulated in cancer. Growing evidence suggests that overactive or abnormal
signaling within and among these pathways may contribute to the survival of
cancer stem cells (CSCs). CSCs are a relatively rare population of cancer cells
capable of self-renewal, differentiation, and generation of serially
transplantable heterogeneous tumors of several types of cancer.
free
free
free
