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10.1093/annonc/mdw555 http://scihub22266oqcxt.onion/10.1093/annonc/mdw555 C5391695!5391695 !28426101     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28426101 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28426101 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Ann+Oncol 2017 ; 28 (2 ): 393-399 Nephropedia Template TP {{tp|p=28426101 |t=2017. Cancer risk among 21st century blood transfusion recipients |pdf=|usr=}}{{28426101 }} gab.com Text Cancer risk among 21st century blood transfusion recipients JO: Ann Oncol http://www.kidney.de/pget.php?&tw=1&pmid=28426101 #FOAvip BACKGROUND: Some carcinogenic viruses are known to be transmissible by blood transfusion. Intensive viral screening of transfused blood now exists in most countries. In the UK, high-sensitivity nucleic acid amplification tests for hepatitis C virus were introduced in 1999 and it was thought that this would reduce, and possibly eliminate, transfusion-related liver cancer. We aimed to investigate cancer risk in recipients of blood transfusion in 2000 or after. METHODS: A total of 1.3 million UK women recruited in 1998 on average were followed for hospital records of blood transfusion and for cancer registrations. After excluding women with cancer or precancerous conditions before or at the time of transfusion, Cox regression yielded adjusted relative risks of 11 site-specific cancers for women with compared to without prior blood transfusion. RESULTS: During follow up, 11 274 (0.9%) women had a first recorded transfusion in 2000 or after, and 1648 (14.6%) of them were subsequently diagnosed with cancer, a mean 6.8 years after the transfusion. In the first 5 years after transfusion there were significant excesses for most site-specific cancers examined, presumably because some had preclinical cancer. However, 5 or more years (mean 8 years) after blood transfusion, there were significant excess risks only for liver cancer (adjusted relative risk?=?2.63, 95%CI 1.45-4.78) and for non-Hodgkin lymphoma (adjusted relative risk?=?1.74, 1.21-2.51). When analyses were restricted to those undergoing hip or knee replacement surgery, the commonest procedure associated with transfusion, these relative risks were not materially altered. CONCLUSIONS: In a large cohort of UK women, transfusions in the 21st century were associated with long-term increased risks of liver cancer and non-Hodgkin lymphoma. Some of these malignancies may have been caused by carcinogenic agents that are not currently screened for in transfused blood. Twit Text FOAVip Cancer risk among 21st century blood transfusion recipients ????Ann Oncol http://www.kidney.de/pget.php?&tw=1&pmid=28426101 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28426101 #FOAvip English Wikipedia <ref>{{Cite pmid|28426101 }}</ref> Cancer risk among 21st century blood transfusion recipients #MMPMID28426101 Yang TO ; Cairns BJ ; Reeves GK ; Green J ; Beral V Ann Oncol 2017[Feb]; 28 (2 ): 393-399 PMID28426101 show ga BACKGROUND: Some carcinogenic viruses are known to be transmissible by blood transfusion. Intensive viral screening of transfused blood now exists in most countries. In the UK, high-sensitivity nucleic acid amplification tests for hepatitis C virus were introduced in 1999 and it was thought that this would reduce, and possibly eliminate, transfusion-related liver cancer. We aimed to investigate cancer risk in recipients of blood transfusion in 2000 or after. METHODS: A total of 1.3 million UK women recruited in 1998 on average were followed for hospital records of blood transfusion and for cancer registrations. After excluding women with cancer or precancerous conditions before or at the time of transfusion, Cox regression yielded adjusted relative risks of 11 site-specific cancers for women with compared to without prior blood transfusion. RESULTS: During follow up, 11 274 (0.9%) women had a first recorded transfusion in 2000 or after, and 1648 (14.6%) of them were subsequently diagnosed with cancer, a mean 6.8 years after the transfusion. In the first 5 years after transfusion there were significant excesses for most site-specific cancers examined, presumably because some had preclinical cancer. However, 5 or more years (mean 8 years) after blood transfusion, there were significant excess risks only for liver cancer (adjusted relative risk?=?2.63, 95%CI 1.45-4.78) and for non-Hodgkin lymphoma (adjusted relative risk?=?1.74, 1.21-2.51). When analyses were restricted to those undergoing hip or knee replacement surgery, the commonest procedure associated with transfusion, these relative risks were not materially altered. CONCLUSIONS: In a large cohort of UK women, transfusions in the 21st century were associated with long-term increased risks of liver cancer and non-Hodgkin lymphoma. Some of these malignancies may have been caused by carcinogenic agents that are not currently screened for in transfused blood. |*Blood Transfusion [MESH] |Breast Neoplasms/*epidemiology [MESH] |Cohort Studies [MESH] |Colorectal Neoplasms/*epidemiology [MESH] |Female [MESH] |Humans [MESH] |Incidence [MESH] |Lung Neoplasms/*epidemiology [MESH] |Middle Aged [MESH]Cancer risk among 21st century blood transfusion recipients (epmc).pdf DeepDyve Pubget Overpricing