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2015 ; 6
(ä): 169
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Cancer microenvironment and inflammation: role of hyaluronan
#MMPMID25926834
Nikitovic D
; Tzardi M
; Berdiaki A
; Tsatsakis A
; Tzanakakis GN
Front Immunol
2015[]; 6
(ä): 169
PMID25926834
show ga
The role of inflammation in the development of cancer was described as early as
the nineteenth century. Abundant evidence supports the preposition that various
cancers are triggered by infection and chronic inflammatory disease whereas,
evading immune destruction has been proposed as one of the new "hallmarks of
cancer." Changes of the tumor microenvironment have been closely correlated to
cancer-mediated inflammation. Hyaluronan (HA), an important extracellular
matrices component, has become recognized as an active participant in
inflammatory, angiogenic, fibrotic, and cancer promoting processes. This review
discusses how HA and specific HA-binding proteins participate in and regulate
cancer-related inflammatory processes.