Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29628997
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Cancer metabolism: New insights into classic characteristics
#MMPMID29628997
Kato Y
; Maeda T
; Suzuki A
; Baba Y
Jpn Dent Sci Rev
2018[Feb]; 54
(1
): 8-21
PMID29628997
show ga
Initial studies of cancer metabolism in the early 1920s found that cancer cells
were phenotypically characterized by aerobic glycolysis, in that these cells
favor glucose uptake and lactate production, even in the presence of oxygen. This
property, called the Warburg effect, is considered a hallmark of cancer. The
mechanism by which these cells acquire aerobic glycolysis has been uncovered.
Acidic extracellular fluid, secreted by cancer cells, induces a malignant
phenotype, including invasion and metastasis. Cancer cells survival depends on a
critical balance of redox status, which is regulated by amino acid metabolism.
Glutamine is extremely important for oxidative phosphorylation and redox
regulation. Cells highly dependent on glutamine and that cannot survive with
glutamine are called glutamine-addicted cells. Metabolic reprogramming has been
observed in cancer stem cells, which have the property of self-renewal and are
resistant to chemotherapy and radiotherapy. These findings suggest that studies
of cancer metabolism can reveal methods of preventing cancer recurrence and
metastasis.
free
free
free
