Cancer biology: a new RING to Wnt signaling
#MMPMID23058807
Fearon ER
; Spence JR
Curr Biol
2012[Oct]; 22
(19
): R849-51
PMID23058807
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The ?-catenin-dependent Wnt signaling pathway has key roles in embryonic
development and adult tissues and is defective in various cancers. Recent studies
highlight the function of two transmembrane RING finger ubiquitin ligases in
modulating Wnt signaling and reveal roles for mutations in the RING finger
proteins in cancer.