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2017 ; 9
(4
): ä Nephropedia Template TP
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Cancer Chemotherapy Specific to Acidic Nests
#MMPMID28425953
Kobayashi H
Cancers (Basel)
2017[Apr]; 9
(4
): ä PMID28425953
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The realization of cancer therapeutics specific to cancer cells with less of an
effect on normal tissues is our goal. Many trials have been carried out for this
purpose, but this goal is still far from being realized. It was found more than
80 years ago that solid cancer nests are acidified, but in vitro studies under
acidic conditions have not been extensively studied. Recently, in vitro
experiments under acidic conditions were started and anti-cancer drugs specific
to acidic areas have been identified. Many genes have been reported to be
expressed at a high level under acidic conditions, and such genes may be potent
targets for anti-cancer drugs specific to acidic nests. In this review article,
recent in vitro, in vivo, and clinical achievements in anti-cancer drugs with
marked efficacy under acidic conditions are summarized, and the clinical use of
anti-cancer drugs specific to acidic nests is discussed.
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