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2018 ; 18
(5-6
): e1700167
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Cancer Associated Fibroblasts: The Architects of Stroma Remodeling
#MMPMID29280568
Santi A
; Kugeratski FG
; Zanivan S
Proteomics
2018[Mar]; 18
(5-6
): e1700167
PMID29280568
show ga
Fibroblasts have exceptional phenotypic plasticity and capability to secrete vast
amount of soluble factors, extracellular matrix components and extracellular
vesicles. While in physiological conditions this makes fibroblasts master
regulators of tissue homeostasis and healing of injured tissues, in solid tumors
cancer associated fibroblasts (CAFs) co-evolve with the disease, and alter the
biochemical and physical structure of the tumor microenvironment, as well as the
behavior of the surrounding stromal and cancer cells. Thus CAFs are fundamental
regulators of tumor progression and influence response to therapeutic treatments.
Increasing efforts are devoted to better understand the biology of CAFs to bring
insights to develop complementary strategies to target this cell type in cancer.
Here we highlight components of the tumor microenvironment that play key roles in
cancer progression and invasion, and provide an extensive overview of past and
emerging understanding of CAF biology as well as the contribution that MS-based
proteomics has made to this field.
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