Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26999601
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26999601
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Clin+Invest
2016 ; 126
(4
): 1242-4
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Cancer s got nerve: Schwann cells drive perineural invasion
#MMPMID26999601
Azam SH
; Pecot CV
J Clin Invest
2016[Apr]; 126
(4
): 1242-4
PMID26999601
show ga
The invasion of cancer cells around and into nerves is associated with increased
cancer aggression and poor patient outcome. As this perineural invasion increases
disease severity, a better understanding of how the process is regulated may help
in the development of therapeutics to target neuronal involvement in cancer. In
this issue of the JCI, Deborde and colleagues show that direct contact between
Schwann cells and cancer cells promotes cancer cell dissociation, migration, and
invasion. Moreover, their data specifically suggest NCAM1 as an important
molecular mediator of this Schwann cell-directed regulation of cancer cells in
perineural invasion. The results of this study provide new insight into the
cellular and molecular mechanisms of perineural invasion.