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2017 ; 8
(1
): 539
Nephropedia Template TP
Maegawa S
; Lu Y
; Tahara T
; Lee JT
; Madzo J
; Liang S
; Jelinek J
; Colman RJ
; Issa JJ
Nat Commun
2017[Sep]; 8
(1
): 539
PMID28912502
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In mammals, caloric restriction consistently results in extended lifespan.
Epigenetic information encoded by DNA methylation is tightly regulated, but shows
a striking drift associated with age that includes both gains and losses of DNA
methylation at various sites. Here, we report that epigenetic drift is conserved
across species and the rate of drift correlates with lifespan when comparing
mice, rhesus monkeys, and humans. Twenty-two to 30-year-old rhesus monkeys
exposed to 30% caloric restriction since 7-14 years of age showed attenuation of
age-related methylation drift compared to ad libitum-fed controls such that their
blood methylation age appeared 7 years younger than their chronologic age. Even
more pronounced effects were seen in 2.7-3.2-year-old mice exposed to 40% caloric
restriction starting at 0.3 years of age. The effects of caloric restriction on
DNA methylation were detectable across different tissues and correlated with gene
expression. We propose that epigenetic drift is a determinant of lifespan in
mammals.Caloric restriction has been shown to increase lifespan in mammals. Here,
the authors provide evidence that age-related methylation drift correlates with
lifespan and that caloric restriction in mice and rhesus monkeys results in
attenuation of age-related methylation drift.
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