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2014 ; 55
(6
): 290-6
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Calcium signaling in lacrimal glands
#MMPMID24507443
Putney JW
; Bird GS
Cell Calcium
2014[Jun]; 55
(6
): 290-6
PMID24507443
show ga
Lacrimal glands provide the important function of lubricating and protecting the
ocular surface. Failure of proper lacrimal gland function results in a number of
debilitating dry eye diseases. Lacrimal glands secrete lipids, mucins, proteins,
salts and water and these secretions are at least partially regulated by
neurotransmitter-mediated cell signaling. The predominant signaling mechanism for
lacrimal secretion involves activation of phospholipase C, generation of the
Ca(2+)-mobilizing messenger, IP3, and release of Ca(2+) stored in the endoplasmic
reticulum. The loss of Ca(2+) from the endoplasmic reticulum then triggers a
process known as store-operated Ca(2+) entry, involving a Ca(2+) sensor in the
endoplasmic reticulum, STIM1, which activates plasma membrane store-operated
channels comprised of Orai subunits. Recent studies with deletions of the channel
subunit, Orai1, confirm the important role of SOCE in both fluid and protein
secretion in lacrimal glands, both in vivo and in vitro.
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