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10.1038/nn.3906 http://scihub22266oqcxt.onion/10.1038/nn.3906 C4651918!4651918 !25531572     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25531572 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25531572 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Neurosci 2015 ; 18 (2 ): 210-8 Nephropedia Template TP {{tp|p=25531572 |t=2015. Calcium dynamics in astrocyte processes during neurovascular coupling |pdf=|usr=}}{{25531572 }} gab.com Text Calcium dynamics in astrocyte processes during neurovascular coupling JO: Nat Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=25531572 #FOAvip Enhanced neuronal activity in the brain triggers a local increase in blood flow, termed functional hyperemia, via several mechanisms, including calcium (Ca(2+)) signaling in astrocytes. However, recent in vivo studies have questioned the role of astrocytes in functional hyperemia because of the slow and sparse dynamics of their somatic Ca(2+) signals and the absence of glutamate metabotropic receptor 5 in adults. Here, we reexamined their role in neurovascular coupling by selectively expressing a genetically encoded Ca(2+) sensor in astrocytes of the olfactory bulb. We show that in anesthetized mice, the physiological activation of olfactory sensory neuron (OSN) terminals reliably triggers Ca(2+) increases in astrocyte processes but not in somata. These Ca(2+) increases systematically precede the onset of functional hyperemia by 1-2 s, reestablishing astrocytes as potential regulators of neurovascular coupling. Twit Text FOAVip Calcium dynamics in astrocyte processes during neurovascular coupling ????Nat Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=25531572 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25531572 #FOAvip English Wikipedia <ref>{{Cite pmid|25531572 }}</ref> Calcium dynamics in astrocyte processes during neurovascular coupling #MMPMID25531572 Otsu Y ; Couchman K ; Lyons DG ; Collot M ; Agarwal A ; Mallet JM ; Pfrieger FW ; Bergles DE ; Charpak S Nat Neurosci 2015[Feb]; 18 (2 ): 210-8 PMID25531572 show ga Enhanced neuronal activity in the brain triggers a local increase in blood flow, termed functional hyperemia, via several mechanisms, including calcium (Ca(2+)) signaling in astrocytes. However, recent in vivo studies have questioned the role of astrocytes in functional hyperemia because of the slow and sparse dynamics of their somatic Ca(2+) signals and the absence of glutamate metabotropic receptor 5 in adults. Here, we reexamined their role in neurovascular coupling by selectively expressing a genetically encoded Ca(2+) sensor in astrocytes of the olfactory bulb. We show that in anesthetized mice, the physiological activation of olfactory sensory neuron (OSN) terminals reliably triggers Ca(2+) increases in astrocyte processes but not in somata. These Ca(2+) increases systematically precede the onset of functional hyperemia by 1-2 s, reestablishing astrocytes as potential regulators of neurovascular coupling. |Animals [MESH] |Astrocytes/cytology/*metabolism [MESH] |Calcium Signaling/*physiology [MESH] |Cerebrovascular Circulation/*physiology [MESH] |Mice [MESH] |Mice, Transgenic [MESH] |Olfactory Bulb/cytology/*metabolism [MESH] |Olfactory Receptor Neurons/metabolism/*physiology [MESH] |Receptor, Metabotropic Glutamate 5/metabolism [MESH]Calcium dynamics in astrocyte processes during neurovascular coupling (epmc).pdf DeepDyve Pubget Overpricing