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2016 ; 25
(5
): 452-8
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Calcium channels in primary cilia
#MMPMID27341444
Nauli SM
; Pala R
; Kleene SJ
Curr Opin Nephrol Hypertens
2016[Sep]; 25
(5
): 452-8
PMID27341444
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PURPOSE OF REVIEW: Primary cilia have become important organelles implicated in
embryonic development, organogenesis, health, and diseases. Although many studies
in cell biology have focused on changes in ciliary length or ciliogenesis, the
most common readout for evaluating ciliary function is intracellular calcium.
RECENT FINDINGS: Recent tools have allowed us to examine intracellular calcium in
more precise locations, that is, the cilioplasm and cytoplasm. Advances in
calcium imaging have also allowed us to identify which cilia respond to
particular stimuli. Furthermore, direct electrophysiological measurement of ionic
currents within a cilium has provided a wealth of information for understanding
the sensory roles of primary cilia. SUMMARY: Calcium imaging and direct
measurement of calcium currents demonstrate that primary cilia are sensory
organelles that house several types of functional calcium channels. Although
intracellular calcium now allows a functional readout for primary cilia,
discussions on the relative contributions of the several channel types have just
begun. Perhaps, all of these calcium channels are required and necessary to
differentiate stimuli in different microenvironments.
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