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10.1016/j.bone.2016.08.022 http://scihub22266oqcxt.onion/10.1016/j.bone.2016.08.022 C5329167!5329167 !27576942     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27576942 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27576942 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Bone 2017 ; 100 (ä): 94-99 Nephropedia Template TP {{tp|p=27576942 |t=2017. Calcium as a cardiovascular toxin in CKD-MBD |pdf=|usr=}}{{27576942 }} gab.com Text Calcium as a cardiovascular toxin in CKD-MBD JO: Bone http://www.kidney.de/pget.php?&tw=1&pmid=27576942 #FOAvip Disordered calcium balance and homeostasis are common in patients with chronic kidney disease. Such alterations are commonly associated with abnormal bone remodeling, directly and indirectly. Similarly, positive calcium balance may also be a factor in the pathogenesis of extra skeletal soft tissue and arterial calcification. Calcium may directly affect cardiac structure and function through direct effects to alter cell signaling due to abnormal intracellular calcium homeostasis 2) extra-skeletal deposition of calcium and phosphate in the myocardium and small cardiac arterioles, 3) inducing cardiomyocyte hypertrophy through calcium and hormone activation of NFAT signaling mechanisms, and 4) increased aorta calcification resulting in chronic increased afterload leading to hypertrophy. Similarly, calcium may alter vascular smooth muscle cell function and affect cell signaling which may predispose to a proliferative phenotype important in arteriosclerosis and arterial calcification. Thus, disorders of calcium balance and homeostasis due to CKD-MBD may play a role in the high cardiovascular burden observed in patients with CKD. Twit Text FOAVip Calcium as a cardiovascular toxin in CKD-MBD ????Bone http://www.kidney.de/pget.php?&tw=1&pmid=27576942 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27576942 #FOAvip English Wikipedia <ref>{{Cite pmid|27576942 }}</ref> Calcium as a cardiovascular toxin in CKD-MBD #MMPMID27576942 Moe SM Bone 2017[Jul]; 100 (ä): 94-99 PMID27576942 show ga Disordered calcium balance and homeostasis are common in patients with chronic kidney disease. Such alterations are commonly associated with abnormal bone remodeling, directly and indirectly. Similarly, positive calcium balance may also be a factor in the pathogenesis of extra skeletal soft tissue and arterial calcification. Calcium may directly affect cardiac structure and function through direct effects to alter cell signaling due to abnormal intracellular calcium homeostasis 2) extra-skeletal deposition of calcium and phosphate in the myocardium and small cardiac arterioles, 3) inducing cardiomyocyte hypertrophy through calcium and hormone activation of NFAT signaling mechanisms, and 4) increased aorta calcification resulting in chronic increased afterload leading to hypertrophy. Similarly, calcium may alter vascular smooth muscle cell function and affect cell signaling which may predispose to a proliferative phenotype important in arteriosclerosis and arterial calcification. Thus, disorders of calcium balance and homeostasis due to CKD-MBD may play a role in the high cardiovascular burden observed in patients with CKD. |Animals [MESH] |Calcium/*metabolism [MESH] |Chronic Kidney Disease-Mineral and Bone Disorder/*metabolism [MESH] |Glucuronidase/metabolism [MESH] |Humans [MESH] |Klotho Proteins [MESH] |Renal Insufficiency, Chronic/metabolism [MESH]Calcium as a cardiovascular toxin in CKD-MBD (epmc).pdf DeepDyve Pubget Overpricing