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2017 ; 18
(2
): ä Nephropedia Template TP
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Calcium Signaling in Interstitial Cells: Focus on Telocytes
#MMPMID28208829
Radu BM
; Banciu A
; Banciu DD
; Radu M
; Cretoiu D
; Cretoiu SM
Int J Mol Sci
2017[Feb]; 18
(2
): ä PMID28208829
show ga
In this review, we describe the current knowledge on calcium signaling pathways
in interstitial cells with a special focus on interstitial cells of Cajal (ICCs),
interstitial Cajal-like cells (ICLCs), and telocytes. In detail, we present the
generation of Ca(2+) oscillations, the inositol triphosphate (IP?)/Ca(2+)
signaling pathway and modulation exerted by cytokines and vasoactive agents on
calcium signaling in interstitial cells. We discuss the physiology and
alterations of calcium signaling in interstitial cells, and in particular in
telocytes. We describe the physiological contribution of calcium signaling in
interstitial cells to the pacemaking activity (e.g., intestinal, urinary, uterine
or vascular pacemaking activity) and to the reproductive function. We also
present the pathological contribution of calcium signaling in interstitial cells
to the aortic valve calcification or intestinal inflammation. Moreover, we
summarize the current knowledge of the role played by calcium signaling in
telocytes in the uterine, cardiac and urinary physiology, and also in various
pathologies, including immune response, uterine and cardiac pathologies.