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10.3390/ijms18020397

http://scihub22266oqcxt.onion/10.3390/ijms18020397
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C5343932!5343932 !28208829
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suck abstract from ncbi


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pmid28208829
      Int+J+Mol+Sci 2017 ; 18 (2 ): ä
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  • Calcium Signaling in Interstitial Cells: Focus on Telocytes #MMPMID28208829
  • Radu BM ; Banciu A ; Banciu DD ; Radu M ; Cretoiu D ; Cretoiu SM
  • Int J Mol Sci 2017[Feb]; 18 (2 ): ä PMID28208829 show ga
  • In this review, we describe the current knowledge on calcium signaling pathways in interstitial cells with a special focus on interstitial cells of Cajal (ICCs), interstitial Cajal-like cells (ICLCs), and telocytes. In detail, we present the generation of Ca(2+) oscillations, the inositol triphosphate (IP?)/Ca(2+) signaling pathway and modulation exerted by cytokines and vasoactive agents on calcium signaling in interstitial cells. We discuss the physiology and alterations of calcium signaling in interstitial cells, and in particular in telocytes. We describe the physiological contribution of calcium signaling in interstitial cells to the pacemaking activity (e.g., intestinal, urinary, uterine or vascular pacemaking activity) and to the reproductive function. We also present the pathological contribution of calcium signaling in interstitial cells to the aortic valve calcification or intestinal inflammation. Moreover, we summarize the current knowledge of the role played by calcium signaling in telocytes in the uterine, cardiac and urinary physiology, and also in various pathologies, including immune response, uterine and cardiac pathologies.
  • |*Calcium Signaling/drug effects [MESH]
  • |Animals [MESH]
  • |Calcium/*metabolism [MESH]
  • |Connective Tissue Cells/classification/*metabolism/ultrastructure [MESH]
  • |Cytokines/metabolism [MESH]
  • |Humans [MESH]
  • |Immunophenotyping [MESH]
  • |Inflammation/metabolism/pathology [MESH]
  • |Interstitial Cells of Cajal/metabolism/ultrastructure [MESH]
  • |Phenotype [MESH]


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