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10.1152/physrev.00034.2013 http://scihub22266oqcxt.onion/10.1152/physrev.00034.2013 C4187032!4187032 !25287861     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25287861 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25287861 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Physiol+Rev 2014 ; 94 (4 ): 1099-142 Nephropedia Template TP {{tp|p=25287861 |t=2014. Calcitonin gene-related peptide: physiology and pathophysiology |pdf=|usr=}}{{25287861 }} gab.com Text Calcitonin gene-related peptide: physiology and pathophysiology JO: Physiol Rev http://www.kidney.de/pget.php?&tw=1&pmid=25287861 #FOAvip Calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide. Discovered 30 years ago, it is produced as a consequence of alternative RNA processing of the calcitonin gene. CGRP has two major forms (? and ?). It belongs to a group of peptides that all act on an unusual receptor family. These receptors consist of calcitonin receptor-like receptor (CLR) linked to an essential receptor activity modifying protein (RAMP) that is necessary for full functionality. CGRP is a highly potent vasodilator and, partly as a consequence, possesses protective mechanisms that are important for physiological and pathological conditions involving the cardiovascular system and wound healing. CGRP is primarily released from sensory nerves and thus is implicated in pain pathways. The proven ability of CGRP antagonists to alleviate migraine has been of most interest in terms of drug development, and knowledge to date concerning this potential therapeutic area is discussed. Other areas covered, where there is less information known on CGRP, include arthritis, skin conditions, diabetes, and obesity. It is concluded that CGRP is an important peptide in mammalian biology, but it is too early at present to know if new medicines for disease treatment will emerge from our knowledge concerning this molecule. Twit Text FOAVip Calcitonin gene-related peptide: physiology and pathophysiology ????Physiol Rev http://www.kidney.de/pget.php?&tw=1&pmid=25287861 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25287861 #FOAvip English Wikipedia <ref>{{Cite pmid|25287861 }}</ref> Calcitonin gene-related peptide: physiology and pathophysiology #MMPMID25287861 Russell FA ; King R ; Smillie SJ ; Kodji X ; Brain SD Physiol Rev 2014[Oct]; 94 (4 ): 1099-142 PMID25287861 show ga Calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide. Discovered 30 years ago, it is produced as a consequence of alternative RNA processing of the calcitonin gene. CGRP has two major forms (? and ?). It belongs to a group of peptides that all act on an unusual receptor family. These receptors consist of calcitonin receptor-like receptor (CLR) linked to an essential receptor activity modifying protein (RAMP) that is necessary for full functionality. CGRP is a highly potent vasodilator and, partly as a consequence, possesses protective mechanisms that are important for physiological and pathological conditions involving the cardiovascular system and wound healing. CGRP is primarily released from sensory nerves and thus is implicated in pain pathways. The proven ability of CGRP antagonists to alleviate migraine has been of most interest in terms of drug development, and knowledge to date concerning this potential therapeutic area is discussed. Other areas covered, where there is less information known on CGRP, include arthritis, skin conditions, diabetes, and obesity. It is concluded that CGRP is an important peptide in mammalian biology, but it is too early at present to know if new medicines for disease treatment will emerge from our knowledge concerning this molecule. |Animals [MESH] |Calcitonin Gene-Related Peptide/chemistry/*genetics/*metabolism [MESH] |Cardiovascular Physiological Phenomena [MESH] |Humans [MESH] |Pain/metabolism [MESH] |Receptors, Calcitonin Gene-Related Peptide/metabolism [MESH]Calcitonin gene-related peptide: physiology and pathophysiology (epmc).pdf DeepDyve Pubget Overpricing