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2015 ; 66
(1
): 133-46
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Calciphylaxis: risk factors, diagnosis, and treatment
#MMPMID25960299
Nigwekar SU
; Kroshinsky D
; Nazarian RM
; Goverman J
; Malhotra R
; Jackson VA
; Kamdar MM
; Steele DJ
; Thadhani RI
Am J Kidney Dis
2015[Jul]; 66
(1
): 133-46
PMID25960299
show ga
Calciphylaxis is a rare but devastating condition that has continued to challenge
the medical community since its early descriptions in the scientific literature
many decades ago. It is predominantly seen in patients with chronic kidney
failure treated with dialysis (uremic calciphylaxis) but is also described in
patients with earlier stages of chronic kidney disease and with normal kidney
function. In this review, we discuss the available medical literature regarding
risk factors, diagnosis, and treatment of both uremic and nonuremic
calciphylaxis. High-quality evidence for the evaluation and management of
calciphylaxis is lacking at this time due to its rare incidence and poorly
understood pathogenesis and the relative paucity of collaborative research
efforts. We hereby provide a summary of recommendations developed by a
multidisciplinary team for patients with calciphylaxis.
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