Cadherins in collective cell migration of mesenchymal cells
#MMPMID22944726
Theveneau E
; Mayor R
Curr Opin Cell Biol
2012[Oct]; 24
(5
): 677-84
PMID22944726
show ga
Immunity, embryogenesis and tissue repair rely heavily on cell migration. Cells
can be seen migrating as individuals or large groups. In the latter case,
collectiveness emerges via cell-cell interactions. In migratory epithelial cell
sheets, classic Cadherins are critical to maintain tissue integrity, to promote
coordination and establish cell polarity. However, recent evidence indicates that
mesenchymal cells, migrating in streams such as neural crest or cancer cells,
also exhibit collective migration. Here we will explore the idea that Cadherins
play an essential role during collective migration of mesenchymal cells.