Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28512623
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Front+Oncol
2017 ; 7
(ä): 73
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Ca(2+) Microdomains in T-Lymphocytes
#MMPMID28512623
Wolf IMA
; Guse AH
Front Oncol
2017[]; 7
(ä): 73
PMID28512623
show ga
Early Ca(2+) signaling is characterized by occurrence of Ca(2+) microdomains
formed by opening of single or clusters of Ca(2+) channels, thereby initiating
first signaling and subsequently activating global Ca(2+) signaling mechanisms.
However, only few data are available focusing on the first seconds and minutes of
Ca(2+) microdomain formation and related signaling pathways in activated
T-lymphocytes. In this review, we condense current knowledge on Ca(2+)
microdomain formation in T-lymphocytes and early Ca(2+) signaling, function of
Ca(2+) microdomains, and microdomain organization. Interestingly, considering the
first seconds of T cell activation, a triphasic Ca(2+) signal is becoming
apparent: (i) initial Ca(2+) microdomains occurring in the first second of T cell
activation, (ii) amplification of Ca(2+) microdomains by recruitment of further
channels in the next 5-10?s, and (iii) a transition to global Ca(2+) increase.
Apparently, the second messenger nicotinic acid adenine dinucleotide phosphate is
the first second messenger involved in initiation of Ca(2+) microdomains.
Ryanodine receptors type 1 act as initial Ca(2+) release channels in CD4(+)
T-lymphocytes. Regarding the temporal correlation of Ca(2+) microdomains with
other molecular events of T cell activation, T cell receptor-dependent
microdomain organization of signaling molecules Grb2 and Src homology [SH2]
domain-containing leukocyte protein of 65?kDa was observed within the first 20?s.
In addition, fast cytoskeletal changes are initiated. Furthermore, the
involvement of additional Ca(2+) channels and organelles, such as the Ca(2+)
buffering mitochondria, is discussed. Future research developments will comprise
analysis of the causal relation between these temporally coordinated signaling
events. Taken together, high-resolution Ca(2+) imaging techniques applied to T
cell activation in the past years paved the way to detailed molecular
understanding of initial Ca(2+) signaling mechanisms in non-excitable cells.
free
free
free
