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10.1016/j.ceca.2014.01.005

http://scihub22266oqcxt.onion/10.1016/j.ceca.2014.01.005
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C4058408!4058408 !24559652
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suck abstract from ncbi


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pmid24559652
      Cell+Calcium 2014 ; 55 (6 ): 362-8
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  • Ca²?-dependent K? channels in exocrine salivary glands #MMPMID24559652
  • Catalán MA ; Peña-Munzenmayer G ; Melvin JE
  • Cell Calcium 2014[Jun]; 55 (6 ): 362-8 PMID24559652 show ga
  • In the last 15 years, remarkable progress has been realized in identifying the genes that encode the ion-transporting proteins involved in exocrine gland function, including salivary glands. Among these proteins, Ca(2+)-dependent K(+) channels take part in key functions including membrane potential regulation, fluid movement and K(+) secretion in exocrine glands. Two K(+) channels have been identified in exocrine salivary glands: (1) a Ca(2+)-activated K(+) channel of intermediate single channel conductance encoded by the KCNN4 gene, and (2) a voltage- and Ca(2+)-dependent K(+) channel of large single channel conductance encoded by the KCNMA1 gene. This review focuses on the physiological roles of Ca(2+)-dependent K(+) channels in exocrine salivary glands. We also discuss interesting recent findings on the regulation of Ca(2+)-dependent K(+) channels by protein-protein interactions that may significantly impact exocrine gland physiology.
  • |Acinar Cells/metabolism [MESH]
  • |Calcium/metabolism [MESH]
  • |Humans [MESH]
  • |Intermediate-Conductance Calcium-Activated Potassium Channels/*metabolism [MESH]
  • |Potassium/*metabolism [MESH]
  • |Protein Interaction Domains and Motifs [MESH]


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