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2015 ; 2015
(ä): 120749
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CT Perfusion Characteristics Identify Metastatic Sites in Liver
#MMPMID26509144
Wang Y
; Hobbs BP
; Ng CS
Biomed Res Int
2015[]; 2015
(ä): 120749
PMID26509144
show ga
Tissue perfusion plays a critical role in oncology because growth and migration
of cancerous cells require proliferation of new blood vessels through the process
of tumor angiogenesis. Computed tomography (CT) perfusion is an emerging
functional imaging modality that measures tissue perfusion through dynamic CT
scanning following intravenous administration of contrast medium. This
noninvasive technique provides a quantitative basis for assessing tumor
angiogenesis. CT perfusion has been utilized on a variety of organs including
lung, prostate, liver, and brain, with promising results in cancer diagnosis,
disease prognostication, prediction, and treatment monitoring. In this paper, we
focus on assessing the extent to which CT perfusion characteristics can be used
to discriminate liver metastases from neuroendocrine tumors from normal liver
tissues. The neuroendocrine liver metastases were analyzed by distributed
parameter modeling to yield tissue blood flow (BF), blood volume (BV), mean
transit time (MTT), permeability (PS), and hepatic arterial fraction (HAF), for
tumor and normal liver. The result reveals the potential of CT perfusion as a
tool for constructing biomarkers from features of the hepatic vasculature for
guiding cancer detection, prognostication, and treatment selection.