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10.3390/ijms160922151 http://scihub22266oqcxt.onion/10.3390/ijms160922151 C4613301!4613301 !26389881     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26389881 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26389881 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Mol+Sci 2015 ; 16 (9 ): 22151-68 Nephropedia Template TP {{tp|p=26389881 |t=2015. CRISPR-Cas9: A Revolutionary Tool for Cancer Modelling |pdf=|usr=}}{{26389881 }} gab.com Text CRISPR-Cas9: A Revolutionary Tool for Cancer Modelling JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26389881 #FOAvip The cancer-modelling field is now experiencing a conversion with the recent emergence of the RNA-programmable CRISPR-Cas9 system, a flexible methodology to produce essentially any desired modification in the genome. Cancer is a multistep process that involves many genetic mutations and other genome rearrangements. Despite their importance, it is difficult to recapitulate the degree of genetic complexity found in patient tumors. The CRISPR-Cas9 system for genome editing has been proven as a robust technology that makes it possible to generate cellular and animal models that recapitulate those cooperative alterations rapidly and at low cost. In this review, we will discuss the innovative applications of the CRISPR-Cas9 system to generate new models, providing a new way to interrogate the development and progression of cancers. Twit Text FOAVip CRISPR-Cas9: A Revolutionary Tool for Cancer Modelling ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26389881 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26389881 #FOAvip English Wikipedia <ref>{{Cite pmid|26389881 }}</ref> CRISPR-Cas9: A Revolutionary Tool for Cancer Modelling #MMPMID26389881 Torres-Ruiz R ; Rodriguez-Perales S Int J Mol Sci 2015[Sep]; 16 (9 ): 22151-68 PMID26389881 show ga The cancer-modelling field is now experiencing a conversion with the recent emergence of the RNA-programmable CRISPR-Cas9 system, a flexible methodology to produce essentially any desired modification in the genome. Cancer is a multistep process that involves many genetic mutations and other genome rearrangements. Despite their importance, it is difficult to recapitulate the degree of genetic complexity found in patient tumors. The CRISPR-Cas9 system for genome editing has been proven as a robust technology that makes it possible to generate cellular and animal models that recapitulate those cooperative alterations rapidly and at low cost. In this review, we will discuss the innovative applications of the CRISPR-Cas9 system to generate new models, providing a new way to interrogate the development and progression of cancers. |*CRISPR-Cas Systems [MESH] |Animals [MESH] |Carcinogenesis/*genetics [MESH] |Gene Targeting/methods [MESH] |Humans [MESH]CRISPR-Cas9: A Revolutionary Tool for Cancer Modelling (epmc).pdf DeepDyve Pubget Overpricing