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2017 ; 66
(7
): 1329-1340
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CRISPR/Cas9: at the cutting edge of hepatology
#MMPMID28487442
Pankowicz FP
; Jarrett KE
; Lagor WR
; Bissig KD
Gut
2017[Jul]; 66
(7
): 1329-1340
PMID28487442
show ga
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 genome
engineering has revolutionised biomedical science and we are standing on the cusp
of medical transformation. The therapeutic potential of this technology is
tremendous, however, its translation to the clinic will be challenging. In this
article, we review recent progress using this genome editing technology and
explore its potential uses in studying and treating diseases of the liver. We
discuss the development of new research tools and animal models as well as
potential clinical applications, strategies and challenges.
|*CRISPR-Cas Systems
[MESH]
|*Gene Editing
[MESH]
|Animals
[MESH]
|Clustered Regularly Interspaced Short Palindromic Repeats/genetics
[MESH]