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10.1016/j.tig.2016.06.004

http://scihub22266oqcxt.onion/10.1016/j.tig.2016.06.004
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suck abstract from ncbi


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pmid27423542
      Trends+Genet 2016 ; 32 (9 ): 526-529
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  • CRISPR Screens to Discover Functional Noncoding Elements #MMPMID27423542
  • Wright JB ; Sanjana NE
  • Trends Genet 2016[Sep]; 32 (9 ): 526-529 PMID27423542 show ga
  • A major challenge in genomics is to identify functional elements in the noncoding genome. Recently, pooled clustered regularly interspersed palindromic repeat (CRISPR) mutagenesis screens of noncoding regions have emerged as a novel method for finding elements that impact gene expression and phenotype/disease-relevant biological processes. Here we review and compare different approaches for high-throughput dissection of noncoding elements.
  • |*Genomics [MESH]
  • |CRISPR-Cas Systems/*genetics [MESH]
  • |Gene Expression Regulation/genetics [MESH]
  • |Genome, Human [MESH]
  • |Humans [MESH]


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