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10.1073/pnas.1519644112 http://scihub22266oqcxt.onion/10.1073/pnas.1519644112 C4697393!4697393 !26644581     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26644581 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (51 ): 15642-7 Nephropedia Template TP {{tp|p=26644581 |t=2015. CREB pathway links PGE2 signaling with macrophage polarization |pdf=|usr=}}{{26644581 }} gab.com Text CREB pathway links PGE2 signaling with macrophage polarization JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26644581 #FOAvip Obesity is thought to promote insulin resistance in part via activation of the innate immune system. Increases in proinflammatory cytokine production by M1 macrophages inhibit insulin signaling in white adipose tissue. In contrast, M2 macrophages have been found to enhance insulin sensitivity in part by reducing adipose tissue inflammation. The paracrine hormone prostaglandin E2 (PGE2) enhances M2 polarization in part through activation of the cAMP pathway, although the underlying mechanism is unclear. Here we show that PGE2 stimulates M2 polarization via the cyclic AMP-responsive element binding (CREB)-mediated induction of Krupple-like factor 4 (KLF4). Targeted disruption of CREB or the cAMP-regulated transcriptional coactivators 2 and 3 (CRTC2/3) in macrophages down-regulated M2 marker gene expression and promoted insulin resistance in the context of high-fat diet feeding. As re-expression of KLF4 rescued M2 marker gene expression in CREB-depleted cells, our results demonstrate the importance of the CREB/CRTC pathway in maintaining insulin sensitivity in white adipose tissue via its effects on the innate immune system. Twit Text FOAVip CREB pathway links PGE2 signaling with macrophage polarization ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26644581 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26644581 #FOAvip English Wikipedia <ref>{{Cite pmid|26644581 }}</ref> CREB pathway links PGE2 signaling with macrophage polarization #MMPMID26644581 Luan B ; Yoon YS ; Le Lay J ; Kaestner KH ; Hedrick S ; Montminy M Proc Natl Acad Sci U S A 2015[Dec]; 112 (51 ): 15642-7 PMID26644581 show ga Obesity is thought to promote insulin resistance in part via activation of the innate immune system. Increases in proinflammatory cytokine production by M1 macrophages inhibit insulin signaling in white adipose tissue. In contrast, M2 macrophages have been found to enhance insulin sensitivity in part by reducing adipose tissue inflammation. The paracrine hormone prostaglandin E2 (PGE2) enhances M2 polarization in part through activation of the cAMP pathway, although the underlying mechanism is unclear. Here we show that PGE2 stimulates M2 polarization via the cyclic AMP-responsive element binding (CREB)-mediated induction of Krupple-like factor 4 (KLF4). Targeted disruption of CREB or the cAMP-regulated transcriptional coactivators 2 and 3 (CRTC2/3) in macrophages down-regulated M2 marker gene expression and promoted insulin resistance in the context of high-fat diet feeding. As re-expression of KLF4 rescued M2 marker gene expression in CREB-depleted cells, our results demonstrate the importance of the CREB/CRTC pathway in maintaining insulin sensitivity in white adipose tissue via its effects on the innate immune system. |Animals [MESH] |Cell Polarity [MESH] |Cyclic AMP Response Element-Binding Protein/*physiology [MESH] |Dinoprostone/*pharmacology [MESH] |Humans [MESH] |Insulin Resistance [MESH] |Interleukin-4/pharmacology [MESH] |Kruppel-Like Factor 4 [MESH] |Kruppel-Like Transcription Factors/physiology [MESH] |Macrophages/*physiology [MESH] |Mice [MESH] |Signal Transduction/*physiology [MESH]CREB pathway links PGE2 signaling with macrophage polarization (epmc).pdf DeepDyve Pubget Overpricing