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10.1111/all.14409 http://scihub22266oqcxt.onion/10.1111/all.14409 C7276803!7276803 !32434272     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32434272 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\32434272 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Allergy 2020 ; 75 (10 ): 2542-2547 Nephropedia Template TP {{tp|p=32434272 |t=2020. COVID-19 Clinical trials: Quality matters more than quantity |pdf=|usr=}}{{32434272 }} gab.com Text COVID-19 Clinical trials: Quality matters more than quantity JO: Allergy http://www.kidney.de/pget.php?&tw=1&pmid=32434272 #FOAvip Despite the ferment aroused in the scientific community by the COVID-19 outbreak and the over 11,000 papers listed in PubMed, published evidence on safe and effective drugs has not progressed yet at the same speed of the pandemic. However, clinical research is rapidly progressing, as shown by the hundreds of registered clinical trials on candidate drugs for COVID-19. Unfortunately, information on protocols of individual studies differs from registry to registry. Furthermore, study designs, criteria for stratification of patients and choice of outcomes are quite heterogeneous. All this makes data sharing and secondary analysis difficult. At last, small single centre studies and the use of drugs on a compassionate basis should be replaced by highly powered, multi-centre, multi-arm clinical trials, in order to provide the required evidence of safety and efficacy of novel or repurposed candidate drugs. Hopefully, the efforts of clinical researchers in the fight against the SARS Cov-2 will result into the identification of effective treatments. To make this possible, clinical research should be oriented by guidelines for more harmonized high-quality studies and by a united commitment of the scientific community to share personal knowledge and data. Allergists and clinical immunologists should have a leading role in this unprecedent challenge. Twit Text FOAVip COVID-19 Clinical trials: Quality matters more than quantity ????Allergy http://www.kidney.de/pget.php?&tw=1&pmid=32434272 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32434272 #FOAvip English Wikipedia <ref>{{Cite pmid|32434272 }}</ref> COVID-19 Clinical trials: Quality matters more than quantity #MMPMID32434272 Bonini S ; Maltese G Allergy 2020[Oct]; 75 (10 ): 2542-2547 PMID32434272 show ga Despite the ferment aroused in the scientific community by the COVID-19 outbreak and the over 11,000 papers listed in PubMed, published evidence on safe and effective drugs has not progressed yet at the same speed of the pandemic. However, clinical research is rapidly progressing, as shown by the hundreds of registered clinical trials on candidate drugs for COVID-19. Unfortunately, information on protocols of individual studies differs from registry to registry. Furthermore, study designs, criteria for stratification of patients and choice of outcomes are quite heterogeneous. All this makes data sharing and secondary analysis difficult. At last, small single centre studies and the use of drugs on a compassionate basis should be replaced by highly powered, multi-centre, multi-arm clinical trials, in order to provide the required evidence of safety and efficacy of novel or repurposed candidate drugs. Hopefully, the efforts of clinical researchers in the fight against the SARS Cov-2 will result into the identification of effective treatments. To make this possible, clinical research should be oriented by guidelines for more harmonized high-quality studies and by a united commitment of the scientific community to share personal knowledge and data. Allergists and clinical immunologists should have a leading role in this unprecedent challenge. |*Research Design [MESH] |Betacoronavirus/*immunology [MESH] |COVID-19 [MESH] |Clinical Trials as Topic/*methods/*standards [MESH] |Coronavirus Infections/*immunology/*therapy [MESH] |Humans [MESH] |Pandemics [MESH] |Pneumonia, Viral/*immunology/*therapy [MESH]COVID-19 Clinical trials: Quality matters more than quantity (epmc).pdf DeepDyve Pubget Overpricing