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2020 ; 510
(ä): 170-176
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COVID-19: Review and hematologic impact
#MMPMID32659224
Letícia de Oliveira Toledo S
; Sousa Nogueira L
; das Graças Carvalho M
; Romana Alves Rios D
; de Barros Pinheiro M
Clin Chim Acta
2020[Nov]; 510
(ä): 170-176
PMID32659224
show ga
In the last decades, coronaviruses have been a major threat to public health
worldwide. SARS-CoV-2 is the third known coronavirus that causes fatal
respiratory diseases in humans. The initial clinical features of SARS-CoV-2
infection are quite nonspecific and not all suspected patients can be tested to
exclude or confirm the diagnosis. Increasing scientific evidence has shown that
abnormalities in routine laboratory tests, particularly hematological tests, have
the potential to indicate, in a quick, practical and economical way, the need for
specific laboratory tests for the diagnosis of SARS-CoV-2 infection, besides
assisting in the prognosis of the disease and in the optimization of its clinical
monitoring. In order to address in a simple and practical way the various aspects
related to SARS-CoV-2 infection, this review reports the history of the virus,
the epidemiology and pathophysiology of COVID-19, with emphasis on its laboratory
diagnosis, particularly in hematological changes found during the course of the
disease.