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2020 ; 510
(ä): 344-346
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COVID-19 infection and thrombosis
#MMPMID32712049
Srivastava S
; Garg I
; Bansal A
; Kumar B
Clin Chim Acta
2020[Nov]; 510
(ä): 344-346
PMID32712049
show ga
BACKGROUND: Recent reports on outbreak of SARS-CoV-2 coronavirus (COVID-19) have
shown its association with abnormal blood clots. The viral infection initiates
inflammatory responses leading to endothelial damage and coagulation cascade
dysfnction. Spread of COVID-19 has been associated with disseminated
intravascular coagulation (DIC) and subsequent coagulopathy. Initially
coagulopathy in COVID-19 patients result in significant elevation of D-dimer,
fibrin/fibrinogen degradation products (FDP), and abnormalities in coagulatory
parameters, which resulting in formation of thrombus and eventually death.
METHODOLOGY: Present report intends to summarize the information of the research
reports available so far on the complications of formation of unusal blood clots
(thrombosis) during COVID-19 infection and its therapeutic strategies. Extensive
web search was done for various reports associating COVID-19 infection with
increased coagulopathy and abnormal coagulatory parameters such as PT, PTT, and
platelet counts; along with increased D-dimer and fibrinogen levels. RESULTS AND
CONCLUSION: Findings of these research reports were summarized to recommend
cautions for clinicians while treating COVID-19 patient. Screening of coagulatory
parameters upon admission and during entire course of treatment is recommended,
especially those who are at increased risk of thrombosis. Also, anticoagulant
treatment can be used as thromboprophylaxis measure. Dose and duration of
anticoagulation treatment requirement may vary and thus regular monitoring is
needed.