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2020 ; 20
(11
): 2983-2988
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COVID-19 and islet transplantation: Different twins
#MMPMID32400017
Piemonti L
; Landoni G
Am J Transplant
2020[Nov]; 20
(11
): 2983-2988
PMID32400017
show ga
For those who work in the field of islet transplantation, the microvascular
coronavirus disease 2019 (COVID-19) lung vessels obstructive thrombo-inflammatory
syndrome (recently referred to as MicroCLOTS) is familiar, as one cannot fail to
recognize the presence of similarities with the instant blood mediated
inflammatory reaction (IBMIR) occurring in the liver hours and days after islet
infusion. Evidence in both MicroCLOTS and IBMIR suggests the involvement of the
coagulation cascade and complement system activation and proinflammatory
chemokines/cytokines release. Identification and targeting of pathway(s) playing
a role as "master regulator(s)" in the post-islet transplant detrimental
inflammatory events could be potentially useful to suggest innovative COVID-19
treatments and vice versa. Scientific organizations across the world are fighting
the COVID-19 pandemic. Islet transplantation, and more generally the
transplantation scientific community, could contribute by suggesting strategies
for innovative approaches. At the same time, in the near future, clinical trials
in COVID-19 patients will produce an enormous quantity of clinical and
translational data on the control of inflammation and complement/microthrombosis
activation. These data will represent a legacy to be transformed into innovation
in the transplant field. It will be our contribution to change a dramatic event
into advancement for the transplant field and ultimately for our patients.
|*Blood Coagulation
[MESH]
|*Pandemics
[MESH]
|*SARS-CoV-2
[MESH]
|Biomarkers/metabolism
[MESH]
|COVID-19/blood/*epidemiology
[MESH]
|Comorbidity
[MESH]
|Complement Activation
[MESH]
|Cytokines/*blood
[MESH]
|Humans
[MESH]
|Islets of Langerhans Transplantation/*methods
[MESH]
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