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2020 ; 22
(5
): 53
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COVID-19 and Cancer: a Comprehensive Review
#MMPMID32385672
Gosain R
; Abdou Y
; Singh A
; Rana N
; Puzanov I
; Ernstoff MS
Curr Oncol Rep
2020[May]; 22
(5
): 53
PMID32385672
show ga
PURPOSE OF REVIEW: The outbreak of the novel coronavirus disease 2019 (COVID-19)
has emerged to be the biggest global health threat worldwide, which has now
infected over 1.7 million people and claimed more than 100,000 lives around the
world. Under these unprecedented circumstances, there are no well-established
guidelines for cancer patients. RECENT FINDINGS: The risk for serious disease and
death in COVID-19 cases increases with advancing age and presence of comorbid
health conditions. Since the emergence of the first case in Wuhan, China, in
December 2019, tremendous research efforts have been underway to understand the
mechanisms of infectivity and transmissibility of severe acute respiratory
syndrome coronavirus-2 (SARS-CoV-2), a fatal virus responsible for abysmal
survival outcomes. To minimize the mortality rate, it becomes prudent to identify
symptoms promptly and employ treatments appropriately. Even though no cure has
been established, multiple clinical trials are underway to determine the most
optimal strategy. Managing cancer patients under these circumstances is rather
challenging, given their vulnerable status and the aggressive nature of their
underlying disease. In this comprehensive review, we discuss the impact of
COVID-19 on health and the immune system of those affected, reviewing the latest
treatment approaches and ongoing clinical trials. Additionally, we discuss
challenges faced while treating cancer patients and propose potential approaches
to manage this vulnerable population during this pandemic.
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